Extensive research over the past quarter-century suggests that curcumin can help counter toxins and influence cell survival through other means. Due to the potent radical-scavenging activity of the curcumins, cultured human skin cells subjected to free radical attack fared better when curcumin or a mixture of the three major curcumins was administered. Furthermore, the three curcumins combined had a greater effect than an equal amount of curcumin, which has led some scientists to claim a synergistic effect from the combination.

• Doctor’s Best Curcumin C3 Complex(R) is a potent antioxidant that protects cells and tissues by fighting free radicals.
• Curcumin C3 Complex(R) contains a standardized extract of Curcuma longa root and supplies 95% total curcuminoids, including curcumin, bisdemethoxy curcumin and demethoxy Curcumin.
• Added add BioPerine(R), an extract of Black Pepper fruit that contains 95-98% piperine, as a natural bioenhancer to enhance absorption.
• Gluten Free, Non-GMO, Soy Free.

The numerous beneficial effects attributed to turmeric root are related to the antioxidant properties of the curcumins it contains. This antioxidant activity can neutralize free radicals that threaten the integrity of cellular structures. Free radicals can cause “oxidative stress,” a process that can trigger cell damage. And oxidative stress is thought to play a role in a variety of diseases. Curcumin C3 Complex(R) has over 50 scientific studies to validate its effectiveness.

Questions & Answers

Q. If I am sensitive to Black Pepper, can I take BioPerine?

A. Yes, only in very rare instances, someone will be found to be sensitive to BioPerine. Those people who are allergic to spices, like peppers, ginger, turmeric, should use piperine-containing products with caution.

Q. What is the difference between Curcumin and Curcumin Phytosome featuring Meriva?

A. In Curcumin Phytosome, each curcuminoid molecule is individually complexed with molecules of the vital cell membrane nutrient phosphatidylcholine (PC). 

By facilitating curcumins’ entry into human cells and tissues, PC gives this product superior bioactivity over non-phytosome curcumin supplements. In human studies, Curcumin Phytosomes were absorbed approximately 10 times better than non-phytosome Curcumins.

Q. What is the country of origin for Doctor’s Best products?

A. Doctor’s Best products are quality tested and manufactured in the United States using highly qualified cGMP manufacturers and raw material ingredients. Doctor’s Best sources raw materials from around the world and ingredients are subject to the intense testing and verification regardless of geography of origin.

Ingredients

?????Doctor’s Best Curcumin C3 Complex(R) features a potent standardised extract of the curcumins from Curcuma longa root. Commonly known as turmeric, Curcuma longa has many culinary uses and is widely known as a spice imparting both colour and flavour to curried dishes. It has likewise been appreciated for centuries in the Indian tradition of holistic health called Ayurveda. The known active components in Curcuma longa are a group of compounds collectively referred to as curcumins.

Cultivated widely in the tropical regions of Asia, Curcuma longa belongs to the ginger family. The underground rhizome of the plant is called “turmeric root”. Marco Polo described turmeric in his accounts of traveling through 13th century China.¹ In addition to its popularity as a spice, turmeric is used as a preservative and as a coloring agent in foods and cosmetics due to the rich yellow color provided by its curcumins.^2,3

Turmeric is named in ancient Ayurvedic and Chinese herbal texts for its support of numerous areas of health. In Ayurveda, turmeric with its curcumins is well documented in helping to support respiratory health, maintenance of joint health, enhancement of liver health, and immune wellness.^4,5 In Northern India, a tonic of fresh turmeric paste with ginger and honey is given to women after childbirth.²

Although the term “curcumin” is sometimes used to describe all the curcumins from turmeric root, the curcumin compound is only the most prominent of the several naturally occurring curcumins in turmeric. Doctor’s Best Curcumin C3 Complex(R) is 95% curcumins, and includes the 3 major curcumins from turmeric: curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). BioPerine(R), an extract of black pepper fruit that contains 95–98% piperine, is added to enhance absorption of the C3 Complex.

Traditional Ayurvedic herbal formulas often include black pepper, and modern scientists who investigated its purpose in such formulas determined that piperine extracted from black peppers promotes intestinal absorption of simultaneously consumed substances.^6-8 For curcumin, which by itself is poorly absorbed into the blood, concomitant administration of piperine with curcumin can increase the bioavailability of curcumin by 2000%.⁹ In a Curcumin C3 Complex(R) trial, one of the first to report on the analysis of tissue curcumin levels in individuals taking curcumin, there was evidence that the curcumin made its way into the cell layer lining the colon.¹⁰

Benefits

Much of the knowledge base about the potential benefits of curcumins has been accumulated through a vast spectrum of preclinical study designs, from in vitro cell culture studies to animal studies that provide a model of how curcumins may work in the human body. Although there are exceptions, curcumin appears to be more bioactive than its sister curcumins DMC and BDMC in these types of research studies.¹¹ Some evidence suggests that a combination of the three major curcumins is superior to curcumin alone.12

Supports healthy joint function

In a randomized, double blind, placebo-controlled trial of 40 men and women, participants were given either placebo capsules or capsules containing 500 mg of Curcumin C3 Complex(R) and 5 mg of BioPerine.¹³ Capsules were taken three times a day (for a total of 1,500 mg of C3 Complex or placebo) for 6 weeks. Measures of joint function, joint comfort, and the quality of daily life were assessed using standardized, commonly administered questionnaires.

Compared with starting measurements, the group taking the curcumins experienced superior joint function and comfort in daily activities after 6 weeks; no significant change was seen in patients taking the placebo capsules. The group taking Curcumin C3 Complex(R) also experienced 13. significantly greater joint function and comfort than the group taking the 14. placebo. The frequency of side effects was no different between the two groups. 15. Several laboratory investigations point to possible mechanisms that might explain the actions of the curcumins seen in the Curcumin C3 Complex(R) trial. The curcumins may help to regulate immune system mediators involved in promoting healthy joint function.14 One group of researchers 17. found that the 3 major curcumins (curcumin, BDMC, and DMC) were the active agents supporting such desirable effects.15,16 18.

Protects cells and tissues by fighting free radicals

The numerous beneficial effects attributed to turmeric root are related to the antioxidant properties of the curcumins it contains. This antioxidant activity can neutralize highly unstable molecules (free radicals) that threaten the integrity of cellular structures. Extensive research over the past quarter-century suggests that curcumin can help counter toxins, as well as influencing cell survival through other means.11,17 This was also shown recently in human lung cells exposed to Curcumin C3 Complex(R).18 Other experimental research done with Curcumin C3 Complex(R) has validated its antioxidant activity when combined with piperine.19

Due to the potent radical-scavenging activity of the curcumins, cultured human skin cells subjected to free radical attack fared better when curcumin or a mixture of the three major curcumins was administered. Furthermore, the three curcumins combined had a greater effect than an equal amount of curcumin, which has led some scientists to claim a synergistic effect from the combination.12

Oral administration of curcumin in rats exposed to a commonly occurring neurotoxin supported the integrity of brain biomolecules (lipids) and promoted levels of glutathione, a major antioxidant present in the human body.20 This and other such preclinical studies suggest that the curcumins provide support for the body’s innate antioxidant defenses.21, 22

Curcumin C3 Complex(R) from Doctor’s Best features an extract of turmeric root standardized to contain its three most prized compounds, with piperine added to enhance absorption. Known primarily for its radical-scavenging activity, this extract actually has a range of beneficial biochemical actions and has been shown to benefit joint health.

Scientific References

1. Pari L, Tewas D, Eckel J. Arch Physiol Biochem 2008; 114:127-49.
2. Hatcher H, Planalp R, Cho J, others. Cell Mol Life Sci 2008; 65:1631-52.
3. Krishnaswamy K. Asia Pac J Clin Nutr 2008;17 Suppl 1:265-8.
4. Goel A, Kunnumakkara AB, Aggarwal BB. Biochem Pharmacol 2008;75:787-809.
5. Ammon HP, Wahl MA. Planta Med 1991;57:1-7.
6. Atal CK, Zutshi U, Rao PG. J Ethnopharmacol 1981;4:229-32.
7. Badmaev V, Majeed M, Prakash L. J Nutr Biochem 2000;11:109-13.
8. Badmaev V, Majeed M, Norkus EP. Nutrition Research 1999;19:381-388.
9. Shoba G, Joy D, Joseph T, others. Planta Med 1998;64:353-6.
10. Irving GR, Howells LM, Sale S, others. Prev Res (Phila) 2013;6:119-28.
11. Anand P, Thomas SG, Kunnumakkara AB, others. Biochem Pharmacol 2008;76:1590-611.
12. Bonte F, Noel-Hudson MS, Wepierre J, Meybeck A. Planta Med 1997;63:265-6.
13. Panahi Y, Rahimnia AR, Sharafi M, others. Phytother Res 2014.
14. Joe B, Rao UJ, Lokesh BR. Molecular and Cellular Biochemistry 1997;169:125-134.
15. Funk JL, Oyarzo JN, Frye JB, others. Journal of Natural Products 2006;69:351-355.
16. Funk JL, Frye JB, Oyarzo JN, others. Arthritis Rheum 2006;54:3452-64.
17. Vareed SK, Kakarala M, Ruffin MT, others. Epidemiol Biomarkers Prev 2008;17:1411-7.
18. Alexandrow MG, Song LJ, Altiok S, others. Eur J Prev 2012;21:407-12.
19. Nilani P, Kasthuribai N, Duraisamy B, others. Anc Sci Life 2009;28:3-6.
20. Rajakrishnan V, Viswanathan P, Rajasekharan KN, Menon VP. Phytother Res 1999;13:571-4.
21. Park SY, Kim HS, Cho EK, others. Food Chem Toxicol 2008;46:2881-7.
22. Cole GM, Teter B, Frautschy SA. Adv Exp Med Biol 2007;595:197- 212.

?* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.